8 de mai. de 2019

Fwd: The New England Journal of Medicine, May 9, 2019

The New England Journal of Medicine  

<http://response.nejm.org/t?ctl=4DB8B:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D

Exclusive Limited-Time Collection: Notable Articles of 2018   
<http://response.nejm.org/t?ctl=4DB8C:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&>   
This annual collection is back, featuring 12 influential studies   
from 2018 that NEJM editors determined were the most   
meaningful in improving medical practice and patient care.   
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copy of Notable Articles of 2018.



THIS WEEK AT NEJM.ORG - May 9, 2019     

Listen to the Weekly Audio Summary     
<http://response.nejm.org/t?ctl=4DB8D:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D

PERSPECTIVE     

Collateral Benefits of Preventive Chemotherapy — Expanding the War   
on Neglected Tropical Diseases   
<http://response.nejm.org/t?ctl=4DB8E:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D>   
P.J. Hotez, A. Fenwick, and D.H. Molyneux | DOI: 10.1056/NEJMp1900400 |   
May 8, 2019   
Free Full Text

Sitting in Limbo — Obamacare under Divided Government   
<http://response.nejm.org/t?ctl=4DB8F:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D>   
J. Oberlander | DOI: 10.1056/NEJMp1903373 | May 8, 2019 

Preying on Prescribers (and Their Patients) — Pharmaceutical   
Marketing, Iatrogenic Epidemics, and the Sackler Legacy
<http://response.nejm.org/t?ctl=4DB90:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
S.H. Podolsky, D. Herzberg, and J.A. Greene | N Engl J Med     
2019;380:1785-1787 | Published Online April 10, 2019   
Audio | Comments

Stopping the Gaps in Epidemic Preparedness     
<http://response.nejm.org/t?ctl=4DB91:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
J.J. Farrar | N Engl J Med 2019;380:1788-1789   
Free Full Text | Audio 

Physician Participation in Lethal Injection     
<http://response.nejm.org/t?ctl=4DB92:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
D.W. Denno | N Engl J Med 2019;380:1790-1791   
Comments

At Baseline     
<http://response.nejm.org/t?ctl=4DB93:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
P.A. Bergl | N Engl J Med 2019;380:1792-1793   
Comments


ORIGINAL ARTICLES       

Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of   
Stroke 
<http://response.nejm.org/t?ctl=4DB94:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
H. Ma and Others | N Engl J Med 2019;380:1795-1803     
CME Exam | Video | Comments     

Transmission of Nipah Virus — 14 Years of Investigations in Bangladesh 
<http://response.nejm.org/t?ctl=4DB95:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
B. Nikolay and Others | N Engl J Med 2019;380:1804-1814

A Randomized Trial of Progesterone in Women with Bleeding in Early     
Pregnancy       
<http://response.nejm.org/t?ctl=4DB96:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
A. Coomarasamy and Others | N Engl J Med 2019;380:1815-1824     
CME Exam       

Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers 
<http://response.nejm.org/t?ctl=4DB97:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
D.L. Bhatt and Others | N Engl J Med 2019;380:1825-1833 | Published     
Online March 17, 2019   

Brief Report: Mesenchymal Hamartoma of the Liver and DICER1 Syndrome   
<http://response.nejm.org/t?ctl=4DB98:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
M. Apellaniz-Ruiz and Others | N Engl J Med 2019;380:1834-1842 

Eculizumab in Aquaporin-4–Positive Neuromyelitis Optica Spectrum       
Disorder       
<http://response.nejm.org/t?ctl=4DB99:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
S.J. Pittock and Others | DOI: 10.1056/NEJMoa1900866 | May 3, 2019     

Targeting Huntingtin Expression in Patients with Huntington's Disease   
<http://response.nejm.org/t?ctl=4DB9A:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
S.J. Tabrizi and Others | DOI: 10.1056/NEJMoa1900907 | May 6, 2019     


REVIEW ARTICLE 

Chronic Kidney Disease of Unknown Cause in Agricultural Communities     
<http://response.nejm.org/t?ctl=4DB9B:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
R.J. Johnson, C. Wesseling, and L.S. Newman | N Engl J Med     
2019;380:1843-1852     
CME Exam       


VIDEOS IN CLINICAL MEDICINE     

How to Perform an Elliptical Excision of the Skin       
<http://response.nejm.org/t?ctl=4DB9C:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
T.J. Saun, J. Truong, S.P. Dev, and K. Wanzel | N Engl J Med   
2019;380:e34   
Video


IMAGES IN CLINICAL MEDICINE     

Metastatic Uveal Melanoma       
<http://response.nejm.org/t?ctl=4DB9D:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
L. Everett and T. Copperman | N Engl J Med 2019;380:1853       

A Pulsatile Abdominal Mass     
<http://response.nejm.org/t?ctl=4DB9E:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
M. Elens and R. Verhelst | N Engl J Med 2019;380:e35   
Video


CASE RECORDS OF THE MASSACHUSETTS GENERAL HOSPITAL     

Case 14-2019: A 44-Year-Old Man with Neck Pain and Swelling     
<http://response.nejm.org/t?ctl=4DB9F:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
P.J. Saylor, D.M. Dudzinski, D.P. Mendoza, and K. Glomski | N Engl J   
Med 2019;380:1854-1863 


EDITORIALS     

Image-Guided Intravenous Alteplase for Stroke — Shattering a Time       
Window 
<http://response.nejm.org/t?ctl=4DBA0:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
R.S. Marshall | N Engl J Med 2019;380:1865-1866

Progesterone for Threatened Abortion   
<http://response.nejm.org/t?ctl=4DBA1:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
M.F. Greene | N Engl J Med 2019;380:1867-1868   

Oligonucleotide Treatment for Huntington's Disease     
<http://response.nejm.org/t?ctl=4DBA2:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
K.H. Fischbeck and N.S. Wexler | DOI: 10.1056/NEJMe1904861 |   
May 6, 2019     


CLINICAL IMPLICATIONS OF BASIC RESEARCH

The Link between Hematopoiesis and Atherosclerosis     
<http://response.nejm.org/t?ctl=4DBA3:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D
M.P.J. de Winther and E. Lutgens | N Engl J Med 2019;380:1869-1871     


CORRESPONDENCE 

Cumulative Probability of Receiving an Antibiotic Prescription over     
Time   
<http://response.nejm.org/t?ctl=4DBA4:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D

Imputability of Adverse Events to Anticancer Drugs     
<http://response.nejm.org/t?ctl=4DBA5:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D

Tafenoquine versus Primaquine to Prevent Relapse of Plasmodium vivax   
Malaria
<http://response.nejm.org/t?ctl=4DBA6:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D

One-Year Outcomes after PCI Strategies in Cardiogenic Shock     
<http://response.nejm.org/t?ctl=4DBA7:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D

Marine n–3 Fatty Acids and Vitamin D Supplementation and Primary       
Prevention     
<http://response.nejm.org/t?ctl=4DBA8:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D

Dapagliflozin and Cardiovascular Outcomes in Type 2 Diabetes   
<http://response.nejm.org/t?ctl=4DBA9:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D

Lactobacillus for Gastroenteritis in Children   
<http://response.nejm.org/t?ctl=4DBAA:F96E9FC9B9717D36CDC834952D6F8143961CAA5EB78719DF&uuid=10014589&dateTime=201905180000&key=KbHIHcTKy%2BC%2B%2F6CpfLqSMbWySEsJJtEmj%2BgLGOJiuHA%3D

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